Kratom Science can be hard to come by, we will keep this page as up to date as we can on any new kratom science we find. The main stream scientific community seems to ignore kratom as a valid herb for either recreational or medical use. We hope that websites like this contribute to more public awareness and thus more scientific study. We encourage young academics to be pioneers of Kratom Science!
Mitragyna speciosa (Kratoms sciency name!)
Mitragyna speciosa, or Kratom, is a tropical deciduous and evergreen tree in the Rubiaceae (Coffee) family. Native to Southeast Asia in the Indochina and Malesia floristic regions, leaves of the kratom tree contain over 40 alkaloids, many of which are psychoactive. Some of the more active alkaloids include mitragynine, mitraphylline, and 7-hydroxymitragynine (what is thought to be the primary active chemical in the leaf).
Kratom behaves as a μ-opioid receptor agonist like codine, so its often used as a treatment for chronic pain, as well as recreationally. Kratom use is not detected by typical drug screening tests, but its metabolites can be detected by more specialized testing. The effects of kratom on humans, including efficacy and safety, currently needs more study, but there is no evidence to date of any harmful side effects.
Kratom also contains at least one alkaloid (rhynchophylline) that is a calcium channel blocker, and reduces NMDA-induced current. Research on the role of NMDA receptor activity in the formation of dependence, and the symptoms of withdrawal is currently underway.
What effects are associated with different doses? (dosage guidelines)
2-6 grams = mild effects (typically the effects are stimulant-like)
7-15 grams = medium strength effects (the effects can be stimulant-like or sedative-euphoric-analgesic)
16-25 grams = strong effects (sedative-euphoric-analgesic effects; too strong for highly sensitive people)
26-50 grams = very strong effects (sedative-euphoric-analgesic effects; TOO STRONG FOR MOST PEOPLE)
By Jason Frumkin